Those runners who’d popped over-the-counter ibuprofen pills before and during the race displayed significantly more inflammation and other markers of high immune system response afterward than the runners who hadn’t taken anti-inflammatories. The ibuprofen users also showed signs of mild kidney impairment and, both before and after the race, of low-level endotoxemia, a condition in which bacteria leak from the colon into the bloodstream. -nytimes
MY COMMENT: Clearly ibuprofen intake prior to and during marathons and ultras poses some serious health risks and no benefit in terms of reducing inflammation or pain (this study looked at Western States 100 competitors).
Some general rules on taking ibuprofen are:
1. Do not take ibuprofen before, during, or shortly after lengthy endurance exercise, especially when there is potential for dehydration.
2. Take ibuprofen with a full glass of water or milk, ideally with meals to avoid stomach irritation.
3. Do not combine ibuprofen with alcohol.
4. Do not take in combination with other medicines, supplements, or herbal products without first consulting with your physician or pharmacist.
5. Avoid if you have a history of any reaction or allergy from another anti-inflammatory medication.
6. Discontinue use immediately if you notice any of the following symptoms: urine that is cloudy or bloody, pain or burning in the stomach, diarrhea or black tarry stools, severe nausea, indigestion or heartburn, vomiting blood.
7. Do not use if you are pregnant or breast-feeding.
8. Talk to your doctor first if you have high blood pressure, liver or kidney disease, heart failure, ulcers or other stomach problems.
-Iburpofen- Friend of Foe (article I wrote a few years ago)