According to AltO2Lab, a company that makes portable altitude simulators, an effective protocol with their device calls for an hour a day of 6 minutes on, 4 minutes off. Unfortunately, I was unable to access the link to their supporting research, but the website claims significant improvement in athletic performance following 15 days compared to a matched placebo group.
Colorado Altitude Training, a company that sells altitude simulator systems, cites this study published in the Journal of Applied Physiology that concludes just the opposite: "Four weeks of a 5:5-min normobaric hypoxia exposure at rest for 70 min, 5 days/wk, is not a sufficient stimulus to elicit improved performance or change the normal level of erythropoiesis in highly trained runners."
I'll keep looking!
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